Focused on different pharmacological aspects of tumor responses to new antitumor drugs. Our specific expertise is concentrated on molecular and cellular biology, in vitro/vivo tests on our murine and human xenografts models:
More than 70 xenograft plus orthotopic and metastatic models are available for the evaluation of new compound efficacy.
All experimental activities are under quality control with GLP - like standard procedures
Drugs screening by tailoring the models to their mechanism of action. Evaluation of antitumor activity of selected agents/rational combinations, in human solid tumor models characterized in terms of expression of relevant targets.

In Vitro Capabilities
Cell proliferation and viability assays:
SRB fluorometric assay Tetrazolium uptake Lactate dehydrogenase (LDH)
Standard assays are available to evaluate:
Migration
Differentiation
Cell Cycle
Apoptosis
In Vivo Capabilities
Bio-imaging to monitor internal tumours & metastases.
- Evalution of tumours with Quantitative Bioluminescent Imaging:
A large panel of bioluminescent pre-clinical models which can be avaluated in real time using the optical molecular imaging system IVIS Spectrum from Caliper Life Sciences.
- Humanised Models:
- Tumour micro-environment imaging:
Dual bioluminescent/fluorescent biological reporters activated by different drugs or environmental stimuli
- Standard immunochemistry methods to evaluate:
- Proliferation, Apoptosis, Necrosis, Angiogenesis
- Diagnostic/biomarker detection
- ELISA analysis of serum and tissues for a comprehensive range of biological targets/marker